Pengaruh Pemberian Dehydroepiandrosterone (DHEA) terhadap Aktivitas Peroksidasi Lipid dan Kadar Nitrit Oksida pada Aorta Tikus Wistar Jantan yang Terpapar Asap Rokok

The research aimed to investigate the effect of dehydroepiandrosterone (DHEA) on lipid peroxidation activity and nitric oxide concentration in aorta male Wistar rats due exposure cigarette smoke. This study was a laboratory experiment using 21 that were divided into 3 groups: KN-14 (negative control is given smoke within 14 days), DHEA-1 (15 mg/kgBW + for DHEA-2 (30 days). carried out 25-45 minutes with 4 cigarettes/day. Surgery performed 15th days remove examine malondialdehyde (MDA) as biomarker (NO) Enzyme-linked Immunosorbent Assay (ELISA). results showed significant increase MDA concentrations found group administered DHEA, particularly at dose 30 (p<0.05). Meanwhile, administration DHEA doses 15 did not have (p>0,05) aortic NO compared KN-14. Therefore, it can be concluded could activity, indicated by concentrations, without affecting exposed days.Keyword: Dehydroepiandrosterone (DHEA), MDA, NO, peroxidation, cigarettes